Built for clinical operations

Clinical payments.
Finally under control.

Replace spreadsheets, email threads, and disconnected tools with one system for budgets, invoices, and payments.

Built for
CROs Sponsors Site Networks
Total paid this quarter
$124,747
Hypha Clinical financial dashboard showing budget summary cards for planned, forecast, accrued, and paid amounts, with a quarterly financial trajectory chart

Your financial workflows are holding your studies back.

Spreadsheets, email threads, and disconnected systems slow down negotiations, create errors, and damage site relationships.

Slow budget negotiations

Manual back-and-forth drags on for weeks, delaying site activation and pushing back your study timelines.

🔁
Redundant data entry

Your team re-enters the same data across multiple tools, costing time and creating compliance risk.

🚨
Payment errors and delays

Sites get frustrated by late, incorrect payments and zero visibility into where their money is.

📉
No financial oversight

Without real-time tracking, budget overruns go unnoticed until it's too late to course-correct.

Four tools. One connected workflow.

Everything your team needs to manage clinical trial finances, from first budget to final payment, with full visibility at every step.

01 / Budget Manager

One system for every budget, version, and approval.

Replace email chains and spreadsheets with a shared workspace where sponsors and sites draft, negotiate, and approve budgets together. Every version tracked, every decision documented.

  • Structured budgets by assessment, visit interval, even milestones
  • Sponsors and sites negotiate, revise, and approve in one shared space
  • Built-in messaging so budgets move forward, not back and forth over email
  • Every change tracked with a full audit trail
  • Budget amendments managed in the same system, not a separate process
Hypha Clinical budget approval workflow showing a line-item budget table with fee categories, tasks, approval statuses, and a multi-step negotiation progress indicator
02 / Invoice Manager

Track every invoice. Catch every discrepancy.

Centralize invoice management so nothing slips through the cracks. Every site knows exactly where their payment stands.

  • Auto-generated invoices from study activity and budget terms
  • Multi-currency support with holdback tracking
  • Paid, approved, and submitted status at a glance
Hypha Clinical invoice list showing invoice numbers, payee names, due dates, payment statuses, and totals including multi-currency support for USD, EUR, and GBP
03 / Payment Manager

Pay sites accurately, on time, every time.

Process payments with confidence. Full audit trails, subject-level payables, and holdback calculations built directly into every invoice.

  • Subject-level CRF payables with overhead calculations
  • Configurable holdback with projected release dates
  • Complete audit trail on every payment decision
Hypha Clinical invoice detail view showing subject-level CRF payables, subtotal, holdback deduction, and grand total for a research site payment
04 / Financial Planning

See where your study finances are going, before it's too late.

Track planned, forecast, accrued, withheld, and paid in one view. Understand enrollment impact on spend and catch overruns before they happen.

  • Financial trajectory charts with enrollment projections
  • Planned vs forecast vs accrued vs paid, all in one dashboard
  • Slice by fee category, site, or time period
Animated demonstration of Hypha Clinical financial planning dashboard showing planned, forecast, accrued, and paid amounts across multiple study quarters with enrollment projections

Up and running in days, not months.

Traditional clinical software implementations can take weeks. Hypha is self-serve. Sign up, configure your study, and start working the same week.

From first budget to final payment, in one place.

Every step of your clinical trial finance workflow, connected.

01
Set up your study

Add your sites, define your fee categories, and build your budget templates. Everything downstream flows from that foundation.

02
Negotiate budgets

Draft budgets and negotiate directly with sites in Hypha. Every version is tracked, every approval is documented, and amendments don't start from scratch.

03
Generate pro-forma invoices

Study activity triggers pro-forma invoices based on your approved budget terms. Review, approve, and track status across every site from one view.

04
Manage payments

Track every payment from approval to disbursement. Full audit trail, holdback management, and real-time financial visibility across the study.

Need the work done, not just the tools?

For teams without a dedicated clinical trial finance function, Hypha offers fully managed services. We handle budget negotiation, invoice generation, and site payments on your behalf. Same platform. Our team running it for you.

Learn more about Managed Services
Hypha Clinical managed services specialist

Ready to fix clinical payments?

See Hypha in action with a personalized demo. No commitments, no long sales cycles.